With the TGV you leave from Lille Europe or Lille Flandres to Avignon TGV station.
With Ouigo, the low-cost brother of the TGV, the shortest journey is 4 hours and 37 minutes non-stop. According to the latest luggage information, the following luggage is included in a OuiGo ticket:
2 pieces of hand luggage, max. 36 x 2 x 15 cm deep.
Or 1 hand luggage of maximum 36 x 27 x 15 cm + 1 luggage of maximum 55 x 35 x 25 cm.
A standard place is the most economical, if you want a power outlet and a quiet place, you can book this.